The stereoselective synthesis of α-amino aldols starting from terminal alkynes.
نویسندگان
چکیده
A new procedure for the stereoselective synthesis of syn α-amino β-oxy ketones is reported. It consists of two steps; in the first step, α-amino silyl enol ethers having a (Z) geometry are prepared from 1-alkynes via 1-sulfonyl-1,2,3-triazoles. In the second step, the silyl enol ethers undergo the TiCl4-mediated Mukaiyama aldol reaction with aldehydes to produce α-amino β-oxy ketones with excellent syn-selectivity.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 72 شماره
صفحات -
تاریخ انتشار 2014